New York: Researchers have found that the heart possesses "sweet taste" receptors, similar to those on our tongues, and stimulating these receptors with sweet substances can modulate the heartbeat.
The discovery opens new avenues for understanding heart function and potentially for developing novel treatments for heart failure. The new research found that these receptors are not just present on heart muscle but also functional.
When the researchers stimulated these receptors in both human and mouse heart cells using aspartame, a common artificial sweetener, they observed a significant increase in the force of heart muscle contraction and accelerated calcium handling – key processes for a healthy heartbeat.
While taste receptors are traditionally associated with the tongue and our ability to perceive flavours, recent studies have shown that these receptors exist in other parts of the body, where they likely play different roles.
This new study is the first to identify specific "sweet taste" receptors, known as TAS1R2 and TAS1R3, on the surface of heart muscle cells.
“After you eat a meal, it's been shown that your heart rate and blood pressure actually are increasing,” said Micah Yoder, a graduate student in the lab of Jonathan Kirk at Loyola University Chicago.
Additionally, their research may explain why high consumption of artificially sweetened beverages is linked to arrhythmogenesis, or an irregular heartbeat.
